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Qu\u2019est-ce qu\u2019un DIN?<\/strong> Num\u00e9ro d\u2019identification du m\u00e9dicament (Drug Identification Number). Une fois qu\u2019un m\u00e9dicament s\u2019est vu attribuer un DIN, cela signifie qu\u2019il a subi avec succ\u00e8s le processus d\u2019examen de Sant\u00e9 Canada et que sa vente est actuellement autoris\u00e9e au Canada. Il s\u2019agit d\u2019un num\u00e9ro \u00e0 8 chiffres qui se trouve sur l\u2019emballage de votre m\u00e9dicament. Il vous est g\u00e9n\u00e9ralement demand\u00e9 d\u2019entrer votre DIN afin d\u2019acc\u00e9der \u00e0 l\u2019information en ligne sur les groupes de soutien aux patients pour les produits biologiques et biosimilaires.<\/p>\n

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Anti-inflammatoires non st\u00e9ro\u00efdiens (AINS):<\/h2>\n<\/div>\n<\/div>\n
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Les anti-inflammatoires non st\u00e9ro\u00efdiens (AINS) agissent en bloquant l\u2019inflammation qui se produit dans la paroi de vos articulations. Ils peuvent \u00eatre tr\u00e8s efficaces pour contr\u00f4ler la douleur et la raideur. En g\u00e9n\u00e9ral, vous constaterez que vos sympt\u00f4mes s\u2019att\u00e9nuent dans les heures qui suivent la prise de ces m\u00e9dicaments, mais l\u2019effet ne dure que quelques heures\u00a0; vous devez donc prendre les comprim\u00e9s r\u00e9guli\u00e8rement. Certaines personnes trouvent que les AINS fonctionnent bien au d\u00e9but, mais deviennent moins efficaces apr\u00e8s quelques semaines. Dans cette situation, il est parfois utile d\u2019essayer un autre AINS. Comme tous les m\u00e9dicaments, les AINS peuvent avoir des effets secondaires. Votre m\u00e9decin r\u00e9duira ce risque en vous prescrivant la dose efficace la plus faible pendant la p\u00e9riode la plus courte possible et en choisissant le meilleur AINS en fonction des autres probl\u00e8mes de sant\u00e9 dont vous pouvez souffrir. Les AINS peuvent provoquer des troubles digestifs (maux d\u2019estomac, indigestions ou l\u00e9sions de la muqueuse de l\u2019estomac). Dans certains cas, les AINS seront prescrits en m\u00eame temps qu\u2019un m\u00e9dicament appel\u00e9 inhibiteur de la pompe \u00e0 protons (IPP) qui aidera \u00e0 prot\u00e9ger l\u2019estomac. Les AINS comportent \u00e9galement un risque accru de crise cardiaque ou d\u2019accident vasculaire c\u00e9r\u00e9bral. Bien que l\u2019augmentation du risque soit faible, votre m\u00e9decin sera prudent avant de vous prescrire des AINS si vous pr\u00e9sentez d\u2019autres facteurs susceptibles d\u2019augmenter votre risque global, par exemple le tabagisme, des probl\u00e8mes de circulation, une pression art\u00e9rielle \u00e9lev\u00e9e, un taux de cholest\u00e9rol \u00e9lev\u00e9 ou le diab\u00e8te. Les AINS les plus fr\u00e9quemment prescrits pour la SA sont le naprox\u00e8ne (Anaprox\u00ae, Naprosyn\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques) et le c\u00e9l\u00e9coxib (Celebrex\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques). D\u2019autres m\u00e9dicaments peuvent \u00eatre prescrits, notamment l\u2019ibuprof\u00e8ne (Advil\u00ae, Motrin\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques), le diclof\u00e9nac (Arthrotec\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques) et le k\u00e9toprof\u00e8ne (divers m\u00e9dicaments g\u00e9n\u00e9riques).<\/p>\n<\/div>\n<\/div>\n<\/div>\n
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M\u00e9dicaments antirhumatismaux synth\u00e9tiques conventionnels modificateurs de la maladie (csDMARD) :<\/h2>\n<\/div>\n<\/div>\n
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ils constituent la premi\u00e8re ligne de traitement avec les AINS, bien que leur efficacit\u00e9 n\u2019ait pas \u00e9t\u00e9 d\u00e9montr\u00e9e. Ces\u00a0m\u00e9dicaments visent \u00e0 emp\u00eacher la SA de s\u2019aggraver et peuvent prendre jusqu\u2019\u00e0 six mois avant que vous ne remarquiez un changement significatif. Pour certains DMARD, vous devrez subir des analyses de sang r\u00e9guli\u00e8res et, dans certains cas, une analyse d\u2019urine \u00e0 intervalles r\u00e9guliers. Ces tests permettent \u00e0 votre m\u00e9decin de surveiller les effets du m\u00e9dicament sur votre \u00e9tat de sant\u00e9, mais aussi de rechercher d\u2019\u00e9ventuels effets secondaires, notamment des probl\u00e8mes au niveau du foie, des reins ou de la formule sanguine. Vous pouvez prendre des AINS en m\u00eame temps que des DMARD, et certaines personnes peuvent avoir besoin de prendre plus d\u2019un DMARD \u00e0 la fois. Il existe de nombreux DMARD, les plus couramment prescrits \u00e9tant le m\u00e9thotrexate (Metoject\u00ae, Rheumatrex\u00ae, Methotrexate Sodium\u00ae, g\u00e9n\u00e9riques) et le l\u00e9flunomide (Arava\u00ae, g\u00e9n\u00e9riques). Un DMARD plus r\u00e9cent qui a \u00e9t\u00e9 approuv\u00e9 est le Tofacitinib (Xeljanz\u00ae) qui cible une enzyme responsable de l\u2019inflammation. D\u2019autres DMARD peuvent \u00eatre utilis\u00e9s dans certaines situations, notamment la sulfasalazine (Salazopyrin\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques), l\u2019azathioprine (Imuran\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques), l\u2019hydroxychloroquine (Plaquenil\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques) et la cyclosporine (Neoral\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques).<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n
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Mol\u00e9cules synth\u00e9tiques cibl\u00e9es<\/h2>\n<\/div>\n<\/div>\n
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les tsDMARDs sont des DMARDs qui ont \u00e9t\u00e9 d\u00e9velopp\u00e9s pour cibler sp\u00e9cifiquement<\/strong> une mol\u00e9cule.<\/p>\n
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*Nous avons inclus dans cette section des informations sur les programmes de soutien aux patients (PSP) offerts avec chaque m\u00e9dicament. Ces programmes comprennent g\u00e9n\u00e9ralement une aide financi\u00e8re, souvent pour faire le pont jusqu\u2019\u00e0 ce que l\u2019assurance du patient prenne en charge le remboursement des m\u00e9dicaments. Certains PSP proposent d\u2019autres offres pour soutenir les patients. Chaque PSP est la propri\u00e9t\u00e9 du fabricant du m\u00e9dicament et peut varier d\u2019une entreprise \u00e0 l\u2019autre.<\/p>\n
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Modificateur de r\u00e9ponse biologique (boDMARD)<\/h2>\n<\/div>\n<\/div>\n
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Les patients atteints de SA peuvent ne pas \u00eatre contr\u00f4l\u00e9s de mani\u00e8re ad\u00e9quate par les AINS et les DMARD, mais peuvent \u00eatre trait\u00e9s par une nouvelle classe de m\u00e9dicaments appel\u00e9s modificateurs de la r\u00e9ponse biologique, ou produits biologiques. Ils sont prescrits par les rhumatologues et sont inject\u00e9s sous la peau ou administr\u00e9s par voie intraveineuse et agissent pour pr\u00e9venir l\u2019inflammation qui peut r\u00e9sulter d\u2019un syst\u00e8me immunitaire hyperactif.<\/p>\n
Biosimilaires (bsDMARD)\u00a0:<\/strong>\u00a0<\/span>De nouveaux types de produits biologiques ont \u00e9t\u00e9 approuv\u00e9s par Sant\u00e9 Canada. Ces derniers sont appel\u00e9s \u00ab\u00a0biosimilaires\u00a0\u00bb. Comme leur nom l\u2019indique, il s\u2019agit de versions similaires (mais non identiques) d\u2019un m\u00e9dicament biologique pr\u00e9c\u00e9demment approuv\u00e9. Les biosimilaires s\u2019inspirent d\u2019un produit biologique d\u00e9j\u00e0 approuv\u00e9, mais comme ils sont grands, complexes et fabriqu\u00e9s dans des cellules vivantes, ce qui introduit un certain niveau de variation naturelle, ils ne sont pas identiques.<\/p>\n
Quelle est la diff\u00e9rence entre biologique et biosimilaire?\u00a0<\/span><\/strong>Les produits biologiques sont une cat\u00e9gorie de traitements d\u00e9riv\u00e9s de cellules vivantes (prot\u00e9ines) qui ciblent des parties sp\u00e9cifiques du syst\u00e8me immunitaire, et il est prouv\u00e9 qu\u2019ils traitent efficacement de nombreuses maladies. Les biosimilaires sont des versions similaires, mais non identiques d\u2019un m\u00e9dicament biologique existant ou original. Les conditions exactes de fabrication des produits biologiques ne sont pas rendues publiques. Ainsi, m\u00eame si les biosimilaires sont fabriqu\u00e9s selon le m\u00eame processus que le produit biologique original, il peut y avoir de petites diff\u00e9rences qui entra\u00eenent des variations dans le produit. Les diff\u00e9rences entre les techniques peuvent inclure le type de cellules utilis\u00e9es pour les produire, la temp\u00e9rature \u00e0 laquelle les cellules sont cultiv\u00e9es, le pH auquel les cellules sont cultiv\u00e9es et les types de nutrition fournis aux cellules. Contrairement aux g\u00e9n\u00e9riques, dont le principe actif est identique \u00e0 celui du m\u00e9dicament de marque, les biosimilaires sont constitu\u00e9s de la m\u00eame prot\u00e9ine que le produit biologique d\u2019origine, mais peuvent pr\u00e9senter de l\u00e9g\u00e8res modifications structurelles dues \u00e0 des diff\u00e9rences de production. Les biosimilaires et les biologiques ont le m\u00eame m\u00e9canisme d\u2019action, c\u2019est-\u00e0-dire qu\u2019ils\u00a0ciblent la m\u00eame voie biologique, et devraient entra\u00eener les m\u00eames avantages et risques avec le traitement.<\/span><\/p>\n
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Opio\u00efdes<\/h2>\n<\/div>\n<\/div>\n
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Opioids<\/strong><\/h3>\n
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Un opio\u00efde n\u2019est pas le premier choix pour traiter des maladies chroniques comme l\u2019arthrite. Mis \u00e0 part la douleur canc\u00e9reuse, les opio\u00efdes sont le plus souvent r\u00e9serv\u00e9s au soulagement de la douleur \u00e0 court terme, comme apr\u00e8s des blessures ou des chirurgies. Lorsque d\u2019autres moyens de soulager la douleur arthritique n\u2019ont pas aid\u00e9, des opio\u00efdes peuvent \u00eatre prescrits. Mais la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9 sont des probl\u00e8mes.<\/p>\n<\/div>\n<\/div>\n<\/div>\n
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Corticost\u00e9ro\u00efdes<\/h2>\n<\/div>\n<\/div>\n
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Ce sont de puissants anti-inflammatoires qui soulagent les douleurs et les gonflements importants. Vous les prenez par voie orale ou sous forme d\u2019injections dans l\u2019articulation. Les corticost\u00e9ro\u00efdes sont souvent utilis\u00e9s pour soulager rapidement les sympt\u00f4mes dans les cas o\u00f9 une ou quelques articulations seulement sont touch\u00e9es. Les injections de st\u00e9ro\u00efdes sont souvent recommand\u00e9es pour les articulations particuli\u00e8rement g\u00eanantes ou lorsque les ligaments et les tendons sont enflamm\u00e9s. Les m\u00e9decins ne prescrivent g\u00e9n\u00e9ralement que ce qui est vraiment n\u00e9cessaire. Si vous les utilisez pendant une longue p\u00e9riode, vous risquez d\u2019avoir des effets secondaires graves tels que l\u2019amincissement de la peau, la fragilisation des os, la prise de poids et le diab\u00e8te. Le corticost\u00e9ro\u00efde oral le plus courant qui peut \u00eatre prescrit est la prednisone (divers g\u00e9n\u00e9riques). Pour les injections intra-articulaires, la m\u00e9thylprednisolone (Depo Medrol\u00ae, divers m\u00e9dicaments g\u00e9n\u00e9riques) est le plus souvent utilis\u00e9e.<\/p>\n<\/div>\n<\/div>\n<\/div>\n
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Ac\u00e9taminoph\u00e8ne<\/h2>\n<\/div>\n<\/div>\n
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L’ac\u00e9taminoph\u00e8ne est utilis\u00e9 pour traiter la douleur associ\u00e9e \u00e0 l’arthrose et, parfois, les formes inflammatoires de l’arthrite comme la spondylarthrite. Il est pris par voie orale sous forme de pilule ou de liquide.<\/p>\n
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R\u00e9sum\u00e9 des m\u00e9dicaments disponibles au Canada<\/strong><\/h3>\n
Nous avons inclus des informations sur les m\u00e9dicaments indiqu\u00e9s pour le psoriasis, la maladie de Crohn et la colite en raison de la pr\u00e9valence significative de ces complications dans la spondylarthrite.<\/p>\n
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N\/A (Non Applicable) = Aucun avis de conformit\u00e9 (ou AC) n\u2019a \u00e9t\u00e9 \u00e9mis pour ce m\u00e9dicament pour cette forme d\u2019arthrite. \u2713= utilis\u00e9 pour traiter cette affection arthritique inflammatoire<\/p>\n
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Avis de non-responsabilit\u00e9: \u00a0\u00a0<\/span><\/strong>Ces informations sont uniquement destin\u00e9es \u00e0 des fins \u00e9ducatives. Consultez toujours votre m\u00e9decin lorsque vous envisagez de commencer un nouveau m\u00e9dicament. Les doses sont approximatives et bas\u00e9es sur la dose recommand\u00e9e pour les adultes. Les doses peuvent varier en fonction de la gravit\u00e9 de la maladie et des besoins individuels. Tous les m\u00e9dicaments \u00e9num\u00e9r\u00e9s sont approuv\u00e9s par Sant\u00e9 Canada dans les affections spondylarthritiques.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n
[\/et_pb_text][et_pb_divider _builder_version=\u00a0\u00bb4.17.4″ _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb theme_builder_area=\u00a0\u00bbpost_content\u00a0\u00bb][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Il existe plusieurs classes de m\u00e9dicaments prescrits pour traiter la spondylarthrite (SpA). Nous avons rassembl\u00e9 ces ressources pour mieux vous aider \u00e0 comprendre les diff\u00e9rents types de traitements pharmacologiques disponibles […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
[et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_post_title author=\"off\" date=\"off\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_post_title][et_pb_image src=\"https:\/\/sparthritis.ca\/wp-content\/uploads\/2022\/08\/Treatments_Cover-1024x384-1.png\" alt=\"Drugs - Banner image\" title_text=\"Pharmacological Treatments Cover image\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" text_text_color=\"gcid-473f3d41-f21a-42db-b6d0-302499fb0d4e\" global_colors_info=\"{%22gcid-473f3d41-f21a-42db-b6d0-302499fb0d4e%22:%91%22text_text_color%22%93}\"]<\/p>
There are several classes of medications prescribed to treat Spondyloarthritis (SpA). We\u2019ve put together these resources to better help you understand the different types of pharmacological treatments available to people with SpA.<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"]<\/p>
Page Contents:<\/strong><\/h4>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text admin_label=\"Bullet List\" _builder_version=\"4.19.5\" _module_preset=\"default\" custom_margin=\"-47px||||false|false\" global_colors_info=\"{}\"]<\/p>
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)<\/li>
Conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs)<\/li>
Targeted Synthetic Molecules<\/li>
Biologic Response Modifiers<\/li>
Corticosteroids<\/li>
Opioids<\/li>
Acetaminophen<\/li>
Summary of Medication Available in Canada<\/li><\/ul>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.19.5\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" background_color=\"gcid-473f3d41-f21a-42db-b6d0-302499fb0d4e\" custom_margin=\"-20px||||false|false\" global_colors_info=\"{%22gcid-473f3d41-f21a-42db-b6d0-302499fb0d4e%22:%91%22background_color%22%93}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_text admin_label=\"What is a DIN\" _builder_version=\"4.19.5\" _module_preset=\"default\" text_text_color=\"#FFFFFF\" text_font_size=\"18px\" background_color=\"RGBA(255,255,255,0)\" custom_padding=\"10px|30px||30px|false|false\" global_colors_info=\"{}\"]<\/p>
What is a DIN?\u00a0<\/strong>Drug Identification Number. Once a drug has been assigned a DIN, it means that it has undergone a successful Health Canada review process and is currently authorized for sale in Canada. It is an 8 digit number that can be found on the packaging of your medication. You are typically required to enter your DIN in order to access the online patient support group information for biologics and biosimilars.<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text admin_label=\"Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)\" _builder_version=\"4.19.5\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
\u00a0<\/p>
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)<\/strong><\/h3>
\u00a0<\/h3>
Non-steroidal anti-inflammatory drugs (NSAIDs) act by blocking the inflammation that occurs in the lining of your joints. They can be very effective in controlling pain and stiffness. Usually you\u2019ll find your symptoms improve within hours of taking these drugs but the effect will only last for a few hours, so you have to take the tablets regularly. Some people find that NSAIDs work well at first but become less effective after a few weeks. In this situation, it sometimes helps to try a different NSAID. Like all drugs, NSAIDs can have side-effects, so your doctor will reduce the risk of these, by prescribing the lowest effective dose for the shortest possible period of time and selecting the best NSAID based on other health conditions you may have. NSAIDs can cause digestive problems (stomach upsets, indigestion or damage to the lining of the stomach) so in some cases NSAIDs will be prescribed along with a drug called a proton pump inhibitor (PPI) that will help to protect the stomach. NSAIDs also carry an increased risk of heart attack or stroke. Although the increased risk is small, your doctor will be cautious about prescribing NSAIDs if there are other factors that may increase your overall risk, for example, smoking, circulation problems, high blood pressure, high cholesterol or diabetes. The most common NSAIDs prescribed for AS include Naproxen<\/p>
\u00a0<\/p>
[\/et_pb_text][et_pb_text admin_label=\"Table\" _builder_version=\"4.19.5\" _module_preset=\"default\" hover_enabled=\"0\" global_colors_info=\"{}\" sticky_enabled=\"0\"][table id=1 column_widths=\"100%\" \/][\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs)<\/strong><\/h3>
\u00a0<\/h3>
csDMARDs are the first line of management along with NSAIDs, although they have not been shown to be very effective. These drugs aim to prevent AS from getting worse, and can take up to six months before you may notice any significant change. For some DMARDs you\u2019ll need to have regular blood tests, and in some cases a urine test at regular intervals. The tests allow your doctor to monitor the effects of the drug on your condition but also to check for possible side effects, including problems with your liver, kidneys or blood count. You can take NSAIDs along with DMARDs, and some people may need to take more than one DMARD at a time. There are many DMARDs available, the most commonly prescribed is Methotrexate (Metoject\u00ae, Rheumatrex\u00ae, Methotrexate Sodium\u00ae, generics) and Leflunomide (Arava\u00ae, Generics). A newer DMARD that has been approved is Tofacitinib (Xeljanz\u00ae) which targets an enzyme responsible for inflammation. Other DMARDs that may be used in certain situations includes sulfasalazine (Salazopyrin\u00ae, various generics), azathioprine (Imuran\u00ae, various generics) , hydroxychloroquine (Plaquenil\u00ae, various generics) and cyclosporin (Neoral\u00ae, various generics).<\/p>
[table id=2 \/]<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Targeted Synthetic Molecules (tsDMARD)<\/strong><\/h3>
\u00a0<\/h3>
* <\/strong>We have included in this section information on the Patient Support Programs (PSP) offered with each medication. These programs usually include financial support, often to offer a bridge until the patient\u2019s insurance takes over reimbursement of the medication. Some PSP\u2019s have other offerings to support patients. Each PSP is owned by the manufacturer of the medication and may vary from one company to the other.<\/p>
[table id=3 \/]<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Biologic response modifiers<\/strong> (boDMARD)<\/strong><\/h3>
\u00a0<\/h3>
Patients with AS may not be adequately controlled by NSAIDs and DMARDs but can be treated by a new class of medications called biologic response modifiers, or biologics<\/em><\/strong>. These are prescribed by rheumatologists and are injected under the skin or given intravenously and work to prevent inflammation that may result from an overactive immune system.<\/p>
Biosimilars (bsDMARD):<\/strong> New types of biologics have been approved by Health Canada. These are called \u201cbiosimilars\u201d. As the name suggests, they are similar (but not identical) versions of a previously approved biologic medication. Biosimilars are modelled after a previously approved biologic but because they are large, complex, and made in living cells introducing some level of natural variation they are not identical.<\/p>
What is the difference between biologic and biosimilar? <\/strong>Biologics are a class of treatments derived from living cells (proteins) that target specific parts of the immune system, and are proven to effectively treat many diseases. Biosimilars are similar but not identical versions of an existing or original biologic medication. The exact conditions for making biologics are not made public, so while biosimilars are made by the same process as the original biologic, there may be small differences resulting in variances in the product. Differences in techniques may include the type of cells used to produce them, the temperature at which the cells are grown, the pH at which the cells are grown, and the types of nutrition provided to the cells. Unlike generics, where the active ingredient is identical to the brand name drug, biosimilars are the same protein as the originator biologic but may have some small structural changes due to differences in production. Biosimilars and biologics have the same mechanism of action, meaning that they target the same biological pathway, and should result in the same benefits and risks with treatment.<\/p>
[table id=4 \/]<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Opioids<\/strong><\/h3>
\u00a0<\/h3>
An opioid isn't the first choice for treating chronic conditions such as arthritis. Aside from cancer pain, opioids more commonly are reserved for short-term pain relief, such as after injuries or surgeries. When other means of relieving arthritis pain haven't helped, opioids may be prescribed. But safety and effectiveness are issues.<\/p>
[table id=7 \/]<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Corticosteroids <\/strong><\/h3>
\u00a0<\/h3>
Corticosteroids are powerful anti-inflammatory drugs that relieve severe pain and swelling. You take them by mouth or in the form of injections into the joint. Corticosteroids are often used for rapid relief of symptoms in cases where only one or a few joints are affected. Steroid injections are often recommended for joints that are particularly troublesome or when ligaments and tendons become inflamed. Doctors typically prescribe only when really needed. If you use them for a long time, you could have serious side effects such as thinned skin, brittle bones, weight gain, and diabetes. The most common oral corticosteroids that may be prescribed is prednisone (various generics). For intra-articular injections, methylprednisolone (Depo Medrol\u00ae, various generics) is most commonly used.<\/p>
[table id=6 \/]<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Acetaminophen<\/strong><\/h3>
\u00a0<\/h3>
Acetaminophen is used to treat pain associated with osteoarthritis and, sometimes, inflammatory forms of arthritis like Spondyloarthritis. It is taken orally in pill or liquid form.<\/p>
[table id=8 \/]<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" custom_margin=\"-95px|auto||auto||\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" min_height=\"537.7px\" global_colors_info=\"{}\"]<\/p>
Summary of Medications Available in Canada<\/strong><\/h3>
\u00a0<\/h3>
We have include information on medications indicated for Psoriasis, Crohn\u2019s and Colitis due to significant prevalence of these complications in Spondyloarthritis<\/p>
[table id=5 \/]<\/p>
Note: <\/strong>
N\/A (Not Applicable) = No Notice of Compliance (or NOC) has been issued for this medication for this form of arthritis.
\u2713= used to treat this inflammatory arthritic condition<\/p>
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_row _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_column type=\"4_4\" _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][et_pb_divider _builder_version=\"4.17.4\" _module_preset=\"default\" global_colors_info=\"{}\"][\/et_pb_divider][et_pb_text _builder_version=\"4.17.4\" _module_preset=\"default\" background_color=\"#E09900\" custom_padding=\"34px|25px||25px|false|false\" global_colors_info=\"{}\"]<\/p>
Disclaimer: This information is for educational purposes only. Always refer to your physician when looking into starting a new medication. Doses are approximate and based on the recommended adult dose. Doses may vary based on disease severity and individual needs. All the medications listed are approved by Health Canada in Spondyloarthritic conditions.<\/p>
\u00a0<\/p>
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